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Browsing by Author "Lamba, Doriano"
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Covaceuszach, Sonia; Cassetta, Alberto; Konarev, Petr V; Gonfloni, Stefania; Rudolph, Rainer; Svergun, Dmitri I; Lamba, Doriano; Cattaneo, Antonino (Elsevier, 2008-09)The anti-nerve growth factor (NGF) monoclonal antibody alphaD11 is a potent antagonist that neutralizes the biological functions of its antigen in vivo. NGF antagonism is expected to be a highly effective and safe therapeutic ...
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Krastanova, Ivet; Guarnaccia, Corrado; Zahariev, Sotir; Degrassi, Giuliano; Lamba, Doriano (Elsevier, 2005-05)Bacillus pumilus PS213 acetyl xylan esterase (AXE) acts as an accessory enzyme in the plant cell wall hemicellulose biodegradation pathway. It belongs to the carbohydrate esterase family 7 and hydrolyses the ester linkages ...
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Paoletti, Francesca; Covaceuszach, Sonia; Konarev, Peter V; Gonfloni, Stefania; Malerba, Francesca; Schwarz, Elisabeth; Svergun, Dmitri I; Cattaneo, Antonino; Lamba, Doriano (Wiley, 2009-06)The unprocessed precursor of the Nerve Growth Factor (NGF), proNGF, has additional functions, besides its initially described role as a chaperone for NGF folding. The precursor protein endows apoptotic and/or neurotrophic ...
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Pesaresi, Alessandro; Devescovi, Giulia; Lamba, Doriano; Venturi, Vittorio; Degrassi, Giuliano (Springer, 2005-02)We purified to homogeneity an intracellular esterase from the opportunistic pathogen Pseudomonas aeruginosa PAO1. The enzyme hydrolyzes p-nitrophenyl acetate and other acetylated substrates. The N-terminal amino acid ...
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Pantano, Sergio; Alber, Frank; Lamba, Doriano; Carloni, Paolo (Wiley, 2002-04)We present an ab initio molecular dynamics study of the complex between acyl carrier protein reductase InhA from M. tuberculosis and isonicotinic acid hydrazide-NADH. We focus on wild-type (WT) InhA and a mutant causing ...
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Covaceuszach, Sonia; Cattaneo, Antonino; Lamba, Doriano (Wiley-Blackwell, 2005-02-05)MNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular ...
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Pesaresi, Alessandro (SISSA, 2005-12-05)
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Paoletti, Francesca; Konarev, Peter V.; Covaceuszach, Sonia; Schwarz, Elisabeth; Cattaneo, Antonino; Lamba, Doriano; Svergun, Dmitri I. (The Biochemical Society, 2006-08)The unprocessed pro-form of the NGF (nerve growth factor), proNGF (NGF precursor, without signal peptide), has been suggested to have additional functions distinct from its role as a promoter of protein folding, i.e. ...
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Structural and Functional Studies of a Polygalacturonase from the Phytopathogen Burkholderia cepaciaMassa, Claudia (2006-12-11)
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Massa, Claudia; Clausen, Mads H.; Stojan, Jure; Lamba, Doriano; Campa, Cristiana (Biochemical Society, 2007-07-13)We have recently isolated and heterologously expressed BcPeh28A, an endopolygalacturonase from the phytopathogenic Gram-negative bacterium Burkholderia cepacia. Endopolygalacturonases belong to glycoside hydrolase family ...
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